What is MR-Platelet-Rich Plasma?
Mononuclear-Cell-Rich Platelet-Rich Plasma (MR-PRP) is a blood product derived from centrifuging a sample of a person's own blood to concentrate the platelets.
PRP is used in a variety of medical and aesthetic treatments because it is believed to promote healing and tissue regeneration. Platelets contain growth factors and other bioactive substances that can stimulate tissue repair and regeneration.
The concept of "dose" in PRP refers to the concentration of platelets. Specifically, the optimal therapeutic dose of platelets is 1 million to 1.5 million platelet per microlitre. This means in a dose of 7 mL there will be 12 billion platelets and a high dose of monocytes required to stimulate the hair bulb. Here's why a higher concentration of platelets might be considered more effective:​​​​​​​​​​​​​​​​​​​​​​​​​​
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​​Increased Growth Factors
Improved Cell Migration + Proliferation
Optimal Concentration + Consistent Results
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​​Increased Growth Factors: The primary rationale behind using PRP is the growth factors and other bioactive molecules stored within the alpha granules of platelets. A higher concentration of platelets would theoretically provide more of these beneficial molecules, leading to increased tissue healing and regeneration.
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Improved Cell Migration and Proliferation: Studies have shown that higher platelet concentrations can increase the migration and proliferation of cells necessary for tissue repair, such as fibroblasts and endothelial cells.
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Optimal Concentration: It's important to note that "higher" doesn't always mean "better." There's an optimal range of platelet concentration where tissue regeneration and healing are maximized. Too few platelets might not provide enough growth factors, but an excessively high concentration might not offer additional benefits and could even be counterproductive.
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Consistent Results: Clinicians and researchers aim to standardize PRP preparations to achieve consistent and reproducible results. By targeting a higher concentration of platelets, they might aim to ensure that every patient gets at least the minimum effective dose.
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Other Components: PRP also contains other cells like leukocytes, which might have roles in inflammation, antimicrobial activity, and tissue repair. The concentration and role of these cells can vary based on the preparation method, and the ideal concentration is still a subject of debate.
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Placebo Effect and Patient Expectation: In some cases, patient beliefs and expectations can play a role. If a patient believes they are receiving a "stronger" or more concentrated treatment, it might amplify their perceived benefits due to the placebo effect.
However, it's crucial to acknowledge that the preparation and use of PRP and the optimal platelet concentration are still topics of ongoing research. While many studies and clinical experiences support the benefits of PRP, there's variability in the reported outcomes. The ideal platelet concentration, the presence of leukocytes, activation methods, and other factors can all influence PRP's effectiveness.
If considering PRP treatment, it's essential to consult with a knowledgeable and experienced physician who can provide guidance based on the latest research and clinical experience.
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BEFORE AND AFTER MR-PRP REGENERATIVE THERAPY
